The Clinical Phenotype of Obese and Overweight Crohnʼs Disease Patients
Bibliographic record
Abstract
Purpose: Investigate the impact of overwight and obese body habitus on the phenotype and clinical course of patients with Crohn's disease (CD). Methods: We retrospectively reviewed the medical records of 117 consecutive patients with CD who presented to the gastroenterology service at the University of Kentucky Medical Center. Patients were seperated based on body mass index (BMI) into three groups: normal weight (BMI: 18.5-24.9), overweight (BMI: 25-29.9) and obese (BMI: >30). Clinical paramaters, including the montreal classification, were compared between groups. The unpaired students t-test was used compare groups. Results: Patients with BMI > 25 were more likely to require surgery for CD (Figure 1), were less likely to have isolated inflammatory (B1) disease and were more likely to have lower serum levels of vitamin D. There was a progressive increase in the proportion of patients with stricturing ileocolonic (L2B2) disease (Figures 2 & 3), and in the proportion needing surgery with increasing BMI. Mean values of serum Vitamin D were lower in patietns with BMI >25 (20 ng/ml) compared to those with BMI < 24.9 (25 ng/ml) (p-value: 0.36). Suprisingly, mean values of C-reactive protein were lower in overweight patients (4 mg/l) compared with normal weight patients (8 mg/l) (p-value:0.20). Conclusion: Compared to normal weight patients with CD, overweight and obese patients (BMI > 25) are more likely to have more severe disease characerized by a higher likelyhood of Vitamin D deficiency, stricturing ileocolonic phenotype, and are more likely to require surgery.FigureFigure
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".