A255 HOSPITALIZATIONS FOR VENOUS THROMBOEMBOLISM ARE INCREASED IN PATIENTS WITH ELDERLY-ONSET INFLAMMATORY BOWEL DISEASE: A POPULATION-BASED MATCHED COHORT STUDY
Bibliographic record
Abstract
Inflammatory bowel disease (IBD) is becoming increasingly common among elderly Canadians. The risk of venous thromboembolism (VTE) in IBD patients increases with age. Compare the incidence of VTE-associated hospitalizations in patients with elderly-onset IBD and non-IBD controls. Incident cases of elderly-onset IBD (≥65y) diagnosed between April 1, 2002 and March 31, 2014 were identified from health administrative data in Ontario using a validated algorithm. Cases were age- and sex-matched to five non-IBD controls. Hospitalizations for VTE were identified from the CIHI Discharge Abstract Database. VTE was defined as deep venous thrombosis (DVT) and/or pulmonary embolism (PE) and could either be the reason for hospitalization or a complication occurring during hospitalization for another reason. The cumulative 5-year risks of VTE, DVT, and PE were calculated for cases and controls. The incidence of VTE, DVT, and PE were compared in cases and controls using a negative binomial model adjusting for comorbidities, rural/urban residence, and income. Results are presented as incidence rate ratios (IRR) and 95% confidence intervals (CI). Analyses were conducted for all types of IBD combined and separately for Crohn’s disease (CD) and ulcerative colitis (UC). We additionally compared the risk of VTE by type of IBD, adjusting for age, sex, comorbidities, rural/urban residence, and income. The 5-year risk of VTE was 5.3% in cases compared to 0.56% in controls (IRR 5.78, 95% CI 4.58–7.30). The incidence of DVT (IRR 7.45, 95% CI 5.38–10.32) and PE (IRR 4.76, 95% CI 3.55–6.39) were similarly increased in IBD. The association persisted when stratifying by disease type (Table). VTE was significantly more common in patients with CD than UC (IRR 1.36, 95% CI 1.03–1.81). DVT and PE were slightly, but not significantly, more common in CD than UC (DVT: IRR 1.35, 95% CI 0.93–1.96; PE: IRR 1.44, 95% CI 0.99–2.08). Elderly patients with IBD are significantly more likely to develop a VTE than people without IBD. Gastroenterologists treating these patients should be aware of the increased risk and future research should seek to identify predictive factors for VTE so that physicians can treat patients with prophylactic measures, when appropriate. Comparison of the risk of VTE in elderly patients with IBD and matched controls CI, confidence interval; DVT, deep venous thrombosis; IRR, incidence rate ratio; PE, pulmonary embolism; VTE, venous thromboembolism CAG, CCC, CIHR
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".