A82 CORRELATION OF MRE INTERPRETATION USING CONSENSUS RECOMMENDATIONS WITH VIDEO CAPSULE ENDOSCOPY IN PEDIATRIC IBD
Bibliographic record
Abstract
Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal (GI) tract which involves small bowel in up to 70% of patients. Detecting intestinal disease represents a challenge as it is inaccessible to upper or lower GI endoscopy, instead requiring magnetic resonance enterography (MRE) and/or video capsule endoscopy (VCE). Jejunal assessment on MRE can be limited if suboptimally distended. VCE is capable of visualizing the entire small bowel but limited to the lumen and more invasive. Few studies have specifically evaluated diagnostic accuracy of MRE for jejunal inflammation in pediatric patients. To determine diagnostic accuracy of MRE compared to VCE for jejunal disease in pediatric patients with suspected or proven CD. Ethics approval was obtained for this retrospective study. Patients ≤ 18 years who had VCE and MRE within 6 months between 2012–2017 at Sickkids Hospital were included. Exclusion criteria were unavailability of VCE report, nondiagnostic/incomplete MRE and non-visualisation of bowel on VCE, with small bowel divided into 5 segments: esophagus/stomach/duodenum, jejunum, proximal ileum, distal ileum and terminal ileum. Blinded review of MRE was performed by a pediatric radiology fellow using recently published MRE consensus guidelines. Data for VCE was obtained from reports. Segments were defined as normal or abnormal for MRE and VCE, specific abnormalities recorded, with statistical analysis for MRE-VCE agreements calculated. The final cohort was 20 patients (13 female), age range 8–17 years (median 16 years), with a time interval between MRE and VCE of 6–172 days (mean 88.1 days). Eighteen MRE were performed at 1.5 Tesla (T), 2 at 3T. MRE was positive in 6 patients (30%) and 9/91 bowel segments (9.9%); VCE was positive in 18 patients (90%) and 47/91 segments (51.6%). MRE-VCE disagreement was mostly due to superficial lesions in the stomach, duodenum and jejunum, including erythema, small ulcers, erosions and vascular ectasia. In these cases the time interval between MRE and VCE was wider, ranging between 60 to 170 days, likely contributing to a higher disagreement rate and lower MRE sensitivity. MRE has high specificity and PPV for detecting small bowel disease, however low sensitivity for detecting superficial lesions in proximal small bowel. MRE: magnetic resonance enterography, VCE: video capsule enterography, Sens: sensitivity, Spec: specificity, PPV: positive predictive value, NPV: negative predictive value. Ferring Scholarship Grant Award
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.071 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".