A141 PREVALENCE OF CELIAC DISEASE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS.
Bibliographic record
Abstract
Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, affecting mostly women. PBC frequently coexists with other autoimmune diseases, including celiac disease (CD). Although the prevalence of CD is high among cohorts with PBC, few studies have directly compared this prevalence to those among individuals with other liver diseases (OLD). To compare the prevalence of CD between a cohort with PBC and a cohort with OLD. Retrospective study from 2013 to 2016. All consecutive patients with an anti-transglutaminase assay requested by a hepatologist and a diagnosis of chronic liver disease were included. The diagnosis of CD had to be confirmed histologically by a small intestinal biopsy. The groups were compared by chi-square tests. We included 399 patients (53.1 years SD 14.0, 54.1% women), including 51 patients with PBC and 348 patients with OLD. The PBC and OLD groups were different for the gender (90.2% vs. 48.9% women, p <0.0001). The prevalence of CD was higher in the group with PBC compared to the group with OLD (11.8 vs 2.9%, p <0.003). In the OLD group, the prevalence of CD was comparable regardless of the etiologic subgroup (NASH 2.7% vs. ROH 4.3%, vs viral 1.5% vs other autoimmune liver diseases 3.3%). The most common reasons for CD screening among PBC patients were the presence of PBC (33.3%) and the etiologic assessment of liver disease (31.4%), whereas for patients with OLD, it was etiologic assessment of liver disease (39.1%) or cytolysis (25.6%). The presence of gastrointestinal symptoms was comparable between PBC and OLD groups (31.4 vs 29.6%, NS). There is a higher prevalence of CD in the PBC group compared to the other liver diseases group. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".