A149 EARLY LIFE EVENTS IN PATIENTS WITH CELIAC DISEASE ARE COMMON AND ASSOCIATE WITH SEVERITY OF CONSTIPATION IN ADULTHOOD.
Bibliographic record
Abstract
Stressful events in childhood have been associated with the development of chronic gastrointestinal disorders in adulthood. However, the role of early life adverse events in patients with celiac disease has been not been investigated. to evaluate the association between early childhood life adverse events (ELE) and gastrointestinal and extra-intestinal symptoms in patients with celiac disease (CD) compared with healthy controls (HC). We enrolled adult patients with biopsy-proven celiac disease attending the celiac clinic at McMaster University, and sex/age-matched HC. ELE were assessed through a semi-structured interview using a modified version of the Adverse Childhood Experience questionnaire. We quantified number of ELE and the presence and severity of gastrointestinal and extra intestinal symptoms. Data are presented as Median (IQR) and n (%). Statistical analysis was performed using Mann-Whitney and Fisher’s exact tests as appropriate. Spearman test was used to assess correlation between ELE and symptoms. We enrolled 44 patients (25 CD patients and 19 HC). CD patients had significantly increased number of ELE compared with HC (7 (3–16) vs. 3 (1–5); p=0.003). The most frequent ELE was substance abuse in family members (CD vs HC p=0.006) and neglectful parenting (CD vs HV p=0.026) during childhood. There was a moderate correlation between ELE and severity of constipation (r2=0.55; p=0.01). No association was found between ELE and diarrhea, abdominal pain or other extraintestinal symptoms. ELE in childhood are frequently found in CD patients and may lead to symptom genesis in adulthood. The association between number of ELE and severity of constipation highlights the need for psychosocial assessment in gastroenterology clinical practice to better understand the pathophysiology of CD and potentially improve the management of these patients. None
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".