Hypofractionated, accelerated radiotherapy to the prostate bed: Five-year outcomes of a prospective phase I/II study.
Bibliographic record
Abstract
7 Background: There have been few studies to date that examine the role of hypofractionated radiotherapy for prostate cancer in the post-operative setting. This study reports on the 5-year outcomes from a single institution, prospective, phase I/II study on hypofractionated prostate bed radiotherapy. Methods: Patients enrolled in this study were all eligible for post-operative radiotherapy and received a prescribed dose of 51Gy in 17 fractions to the prostate bed. On subsequent follow-up, GI/GU toxicity was assessed using the NCI CTCAE v3.0, PSA was evaluated and quality-of-life was assessed using the EPIC questionnaire. Results: A total of 30 patients were enrolled between 2008 and 2011. Median age was 65 [52-75] years. Median pre-treatment PSA was 0.12 ng/ml [0.01-1.42]. Twenty-four (86%) patients had Gleason 7 disease, 13 (43%) had pT3 disease and 20 (67%) had positive margins. Twenty-six (87%) patients underwent radiotherapy as salvage treatment. No patient experienced CTCAE grade 3/4 toxicity. Two (7%) patients experienced at least one CTCAE grade 2 late GI toxicity and 11 (37%) had at least one late grade 2 GU toxicity. At baseline and 5 years post radiotherapy, mean EPIC urinary domain score were 80 (SD: 18) and 82 (17). Mean EPIC bowel domain score were 93 (13) and 93 (15). One (4%) patient had a minimally clinically important change (MCIC) in urinary domain score and 1 (4%) patient had a MCIC in bowel domain score. Nelson-Aalen estimated cumulative incidence of biochemical failure were 31% (nadir+0.2) and 18% (nadir+2.0) at 5 years. Four-year PSA ≥0.4 was highly predictive of subsequent rise to nadir+2.0 at 5 years (Nelson-Aalen cumulative hazard: 1.45; standard error: 0.701; p < 0.0001). Five (17%) patients received hormonal therapy for biochemical failure. Nelson-Aalen estimated cumulative incidence of hormone therapy use was 14% at 5 years. Conclusions: In this phase I/II study, hypofractionated post-operative radiotherapy appears to have good clinical efficacy without significant late toxicity. Phase III studies are warranted. Clinical trial information: 042-2009.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".