The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.011
- Threshold uncertainty score
- 0.898
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.011 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.255 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- European Journal of Epidemiology
- Topic
- Obesity, Physical Activity, Diet
- Field
- Medicine
- Canadian institutions
- not available
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. National Library of MedicineNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Human Genome Research InstituteNational Institute of Mental HealthSchool of Public Health, Imperial College LondonNational Institute on Alcohol Abuse and AlcoholismRegion SjællandManchester Biomedical Research CentreRIKENInstituto de Salud Carlos IIIFoundation for Cardiovascular ResearchGreat Ormond Street Institute of Child HealthTurun YliopistoForsknings- og InnovationsstyrelsenNational Institute of Allergy and Infectious DiseasesDanish Agency for Science and Higher EducationNational Institutes of HealthTurun YliopistosäätiöCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas AsociadasDiabetestutkimussäätiöSuomen KulttuurirahastoTurun Yliopistollinen KeskussairaalaGovernment of Western AustraliaNovo Nordisk FondenNational Institute on AgingDet Sundhedsvidenskabelige Fakultet, Københavns UniversitetUniversity of North Carolina at Chapel HillPaavo Nurmen SäätiöTampereen TuberkuloosisäätiöSydäntutkimussäätiöU.S. Department of Veterans AffairsBeyond BlueRegion HovedstadenUniversity of PennsylvaniaSigne ja Ane Gyllenbergin SäätiöDiamantina Institute, University of QueenslandCancer Research UKPerelman School of Medicine, University of PennsylvaniaJuho Vainion SäätiöEuskal Herriko UnibertsitateaGentofte HospitalImperial College LondonFaculty of Tropical Medicine, Mahidol UniversityGeneralitat de CatalunyaGeneralitat ValencianaBritish Heart FoundationMinisterio de Economía y CompetitividadUniversity of ExeterChildren's Hospital of PhiladelphiaSundhed og Sygdom, Det Frie ForskningsrådMurdoch UniversityNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Health and Medical Research CouncilOulun YliopistoEdith Cowan UniversityNational Cancer InstituteEuropean Regional Development FundAcademy of FinlandCurtin University of TechnologyNational Heart, Lung, and Blood InstituteUniversiteit LeidenRaine Medical Research FoundationUniversity of BristolVrije Universiteit AmsterdamUniversity of OxfordUniversité de LausanneLundbeckfondenUniversity College LondonFaculty of Medicine, Dentistry and Health Sciences, University of Western AustraliaLunds UniversitetFaculty of Health and Medical Sciences, University of Western AustraliaMax Planck Instituut voor PsycholinguïstiekWellcome TrustHorizon 2020 Framework ProgrammeNovo NordiskVetenskapsrådetAsthma and Lung UKAgència de Gestió d'Ajuts Universitaris i de RecercaLastentautien TutkimussäätiöNational Institute for Health and Care ResearchUniversitat Pompeu FabraCanadian Institutes of Health ResearchSigrid Juséliuksen SäätiöDiabetes UKAustralian GovernmentEusko JaurlaritzaInnovationsfondenHelsingin YliopistoSteno Diabetes Center CopenhagenMedical Research CouncilFundació la Marató de TV3Yrjö Jahnssonin SäätiöHjerteforeningenNovo Nordisk Foundation Center for Basic Metabolic ResearchUniversity of Notre DameAugustinus FondenEmil Aaltosen SäätiöItä-Suomen YliopistoDiabetesliittoLeids Universitair Medisch CentrumMahidol University
- Keywords
- MedicineEpidemiologyEarly childhoodPopulationHeritabilityMedical geneticsDiseaseTwin studyGerontologyDemographyPsychiatryGeneticsDevelopmental psychologyEnvironmental healthBiologyPsychologyPathology
- Has abstract in OpenAlex
- yes