A188 BIRTH COHORT SCREENING FOR HEPATITIS C IN AN OUTPATIENT ENDOSCOPY UNIT: INTERIM RESULTS.
Bibliographic record
Abstract
Chronic hepatitis C (HCV) is a curable asymptomatic infection and it is estimated that as many as 70% of infected patients remain undiagnosed. The Canadian Liver Foundation recommends one-time HCV screening in all Canadians born from 1945–1975. The aim of this study is to determine the acceptance, feasibility and cost effectiveness of an HCV screening program in this birth cohort in an outpatient endoscopy setting. Here we present the interim results. We are conducting a 12-month prospective cohort study of individuals born from 1945–1975 presenting to the outpatient endoscopy unit at the Kingston Health Sciences Centre. Patients scheduled for an endoscopic procedure within this birth cohort who do not have results of previous HCV testing are approached for inclusion. After informed consent, HCV screening is performed using the point-of-care OraSure® test for the HCV antibody. Those with a positive screening test have blood sent to Public Health Ontario for HCV RNA and genotyping. If RNA positive, they are linked to care. During the first 6 months, 55% (628/1145) of eligible patients were approached for inclusion (Table) and 83% (522/628) consented for HCV screening (50% female, median age 62 years [IQR 55–68 years], 87% Caucasian race). Of those who consented, 85% of patients had no previous HCV screening and 6% were screened but unaware of their screening status. Overall, 0.8% (4/522) of patients screened positive for the HCV antibody using the OraSure® test. All four patients have been seen in outpatient follow-up and are undergoing evaluation for HCV therapy. The majority of patients born from 1945–1975 presenting for outpatient endoscopy have not been screened for HCV. This identifies a target population for the development of an HCV screening program with a goal of to increasing HCV identification and facilitating linkage to care. The final results of this study will be used to perform a cost-effective analysis of the implementation of this model of HCV screening. Southeastern Ontario Academic Medical Organization (SEAMO) Innovation Fund and Gilead Canada.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".