226. LONGITUDINAL ASSOCIATION OF VASCULITIS DISEASE INDEX AND PATIENT-REPORTED OUTCOMES IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIDES
Bibliographic record
Abstract
Background: ANCA-associated vasculitides (AAV) are rare multi-system diseases causing significant organic and functional morbidity. The Vasculitis Disease Index (VDI) is a physician-based tool that measures disease related damage; whereas the self-reported Health Assessment Questionnaire (HAQ) is commonly used to assess patients’ functional status and predicts long-term disability. The objective of this study is to determine the relationship between VDI, HAQ and other patient-reported outcomes over the course of disease. Methods: A retrospective chart review was performed for all AAV patients seen at St. Joseph’s Healthcare (London, Canada). For each patient, baseline demographics, clinical information, VDI, and patient-reported scores (HAQ, pain and global) were collected from point of initial contact (visit 0) and every 3 months (if active disease) to every 6 months (if remission). A mixed-model repeated measures regression analysis was undertaken using SPSSv21.0 with VDI as the dependent variable and patient-reported scores as covariates where the model accounted for within/between patient differences (subject variable) and visits (repeated measure). Missing data was excluded pair-wise (<10%). Results: A total of 93 patients were included with an average age of 60.2 years (SD = 17.6), 51/93 (55%) males, 87/93 (94%) Caucasian and 6/93 (6.5%) deaths. 57 (61%) had a diagnosis of GPA, 27 (29%) EGPA and 9 (9.7%) MPA; 48 (52%) were positive for anti-PR3/cANCA and 29 (31%) anti- MPO/pANCA. In addition to corticosteroids, induction therapies used were Cyclophosphamide (57%) and Rituximab (43%). The most frequently used maintenance therapies were Azathioprine (39/93) and Methotrexate (50/93). The mean duration of follow-up was 35.6 months (SD = 26) and the mean duration of disease activity was 6.7 years (SD = 5.6). Figure 1 depicts mean scores over time. The regression analysis showed a significant association between VDI and HAQ (HAQ score increases by 0.64 (SE = 0.17) for one unit increase in VDI) (p-value < 0.0001). There was no significant relationship between VDI and other patient-reported outcomes. Conclusion: Our study shows a significant positive relationship between VDI and HAQ scores over the follow-up period, indicating that increased organic damage correlates with worsening function over-time. Calculating VDI scores during clinic visits should be considered a standard practice. Graphical representation of mean scores over time of VDI, HAQ, pain and global scores. Error bar represents 95% confidence interval. Disclosures: None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".