Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle‐dependent manner
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Bibliographic record
Abstract
Abstract The dermal papilla ( DP ) is one of two principal mesenchymal compartments of the hair follicle ( HF ). We previously reported that a population of HF dermal stem cells (hf DSC s) function to regenerate the dermal sheath ( DS ), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HF s and support the production of large hair fibres. Here, we asked whether injury altered the behaviour of hf DSC s and their progeny in order to support wound‐induced hair growth ( WIHG ) and if the response was modulated by hair cycle stage. α SMAC re ER T 2 : ROSA YFP mice received tamoxifen to label the DS , including hf DSC s. Full‐thickness excisions were made on the dorsal skin during various stages of the hair cycle. The skin was harvested at the subsequent anagen. Interestingly, there was an increase in the magnitude of recruitment of hf DSC progeny into the DP after injury compared to follicles entering natural second anagen. This bias towards a DP fate only occurred when a wound was induced during certain stages of the HC . In summary, injury modifies the fate of hf DSC s progeny, biasing them towards recruitment into the DP , with the hair cycle stage also influencing this response.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it