T17. ACUTE CONCEPTUAL DISORGANIZATION IN UNTREATED FIRST-EPISODE PSYCHOSIS: A 7T DTI STUDY OF CINGULUM TRAC
Bibliographic record
Abstract
The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in psychosis. Cingulum tract carries fibers that connect medial prefrontal structures with precuneus, thus serving as the major pathway within the default mode network (DMN), critical for self-related processing. Persistent disorganization (or formal thought disorder) is largely considered to be a language-related dysfunction, though the neural basis of acute disorganization is yet unknown. We studied bilateral cingulum tract to identify if fractional anisotropy (indicating reduced white matter integrity) differed between patients with high vs. low levels of conceptual disorganization at first presentation, before initiating treatment. We used ultra-high resolution (7 Tesla) diffusion weighted imaging in 40 patients with first-episode psychosis and 25 controls, to investigate bilateral cingulum, defined according to JHU white matter atlas. Based on the conceptual disorganization scores of PANSS, we divided patients in to 2 groups, low (P2=1,2,3) and high (P2=4,5,6) groups. These two groups were not different in their severity of other positive and negative symptoms. TBSS was applied to compare fractional anisotropy (FA) values using FSL software and permutation (5000) correction was used within the selected tract. F tests were used for group comparisons. We undertook post-hoc comparisons of radial diffusivity (reflecting myelin content), axial diffusivity (reflecting axonal integrity) and mode of anisotropy (reflecting fiber organization) for the regions showing significant FA abnormalities. There was a significant reduction in FA (p=0.036) in a cluster in left cingulum, with high P2 groups showing lower values than low P2 and controls. Post hoc showed that high P2 group had lower AD values compared to low P2 group (P=0.021). Interestingly, we also noted that patients with low P2 group had significantly higher AD values than healthy controls, indicating resilience from disorganization conferred by increased cingulum integrity. We did not find any significant difference in RD and MO value among the 3 groups. These FA differences were not explained by the distribution of other symptom scores. Our findings suggest that acute conceptual disorganization may relate to white matter damage of cingulum, the microstructural organization of which is critical for functional synchronization within the default mode network. We propose that the neural correlates of acute conceptual disorganization may differ from those of chronic, persistent formal thought disorder, in that language areas are less likely to be involved in acute disorganization.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".