T27. DEPRESSIVE SYMPTOMS ARE ASSOCIATED WITH DURATION OF UNTREATED PSYCHOSIS (DUP) IN ANTIPSYCHOTIC NAIVE FIRST EPISODE PSYCHOSIS (FEP)
Bibliographic record
Abstract
Depressive symptoms are common on first episode psychosis, with a prevalence of up to 83% of a full depressive episode. These symptoms are related to worst functionality and higher suicide rates. In literature, longer duration of untreated psychosis (DUP) and a worse premorbid are related to these symptoms. DUP is one of the most modifiable factors on FEP, with shorter DUP predicting better outcomes in patients with schizophrenia. Only a few studies explore the relation between depressive symptoms and DUP, with no studies in a Brazilian population. Therefore, our aim was to investigate the association between depressive symptoms, functionality and DUP of antipsychotic naive-FEP (AN-FEP) patients in a 10-week follow-up study. We recruited 88 AN-FEP patients with first episode psychosis admitted to a psychiatric emergency service. We assessed diagnosis according to Structured Clinical Interview for DSM-IV (SCID-I). Depressive symptoms were measured with the depressive dimension of Positive and Negative Symptoms Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Clinical Global Impression Scale (CGI-S). We adopted the CDSS cut-off of 6, according to the Brazilian validation. All patients were treated with risperidone and revaluated after 10 weeks. For analysis, we performed non-parametric correlation tests (Spearman’s correlation). Prevalence of depressive syndrome according to CDSS was 20.4% at baseline, and 11.1% after treatment. Also, 4,6% of the patients started an antidepressant treatment. We found a mean DUP of 166 days (SD = 282, median = 47 days). We found a correlation between DUP and depressive dimension at baseline (r = -0.397; p < 0.001) and on follow-up (r = -0.322, p = 0.012). At both assessments, CDSS and the depressive scale of CGI-S scores did not show significant correlation with DUP. Prevalence of depression and median DUP was in line with the worldwide range. Surprisingly, this is the first study that shows a negative correlation between depressive symptoms and DUP, which is opposite to what most studies demonstrates and to what we expected. Depression is a common feature in FEP, yet their risk factors remain unclear. The relation between DUP and depressive symptoms should be more studied to understand the real influence of DUP in these patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".