Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
RationaleAccurate estimation of gestational age (GA) using DNA methylation (DNAm) of umbilical cord blood, a novel development, provides relevant information on developmental stage. Studies of environmental exposures on GA are plentiful, but not using DNAm GA. We evaluated associations between DNAm GA, environmental correlates of the built environment and atopy.MethodsCord blood samples from 145 selected participants in the Canadian Healthy Infant Longitudinal Development study were examined, together with allergy skin prick tests at age 1 year.Exposure to greenness using satellite imagery, and individual exposure estimates to air pollution using land use regression models were assessed at home addresses throughout pregnancy.Associations of air pollution and greenness with DNAm GA residuals were tested while adjusting for maternal and neonatal characteristics. We further examined whether sensitization related to these environmental factors and DNAm GA.ResultsThe mean GA was 276 (SD: 7.9) days, and mean DNAm GA was 279(5.8) days. There was a significantly positive correlation between these measues (r=0.66; p<0.001).Prenatal exposure to greenness showed borderline association with DNAm GA acceleration (i.e., older DNAm GA than chronological GA) (0.6 days, 95% CI: [-.6; 1.8] for one IQR exposure increase). Conversely, DNAm GA deceleration (i.e., younger DNAm GA) was associated with air pollution exposure during the first trimester (-2.1 days [-4.8; 0.7] for a 10 μg/m3 exposure increase).29% of this atopy-enriched sub-cohort were sensitized to at least one of 10 allergens. DNAm GA was a strong predictor of decreased risk of sensitization (OR: 0.93, 95%CI: [0.88; 0.99]), while air pollution exposure modestly increased the risk of sensitization by 4% (p=0.1).ConclusionOur findings warrant in depth investigation of potential mediating role of DNA methylation on the association between allergic disorders and the built environment.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it