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Record W2937883307 · doi:10.1016/j.chom.2019.03.002

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity

2019· article· en· W2937883307 on OpenAlex
Nirmin Alsahafi, Nordine Bakouche, Mohsen Kazemi, Jonathan Richard, Shilei Ding, Sudipta Bhattacharyya, Durba Das, Sai Priya Anand, Jérémie Prévost, William D. Tolbert, Hong Lü, Halima Medjahed, Gabrielle Gendron‐Lepage, Gloria Delgado, Sharon Kirk, Bruno Melillo, Walther Mothes, Joseph Sodroski, Amos B. Smith, Daniel E. Kaufmann, Xueling Wu, Marzena Pazgier, Isabelle Rouiller, Andrés Finzi, James B. Munro

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueCell Host & Microbe · 2019
Typearticle
Languageen
FieldImmunology and Microbiology
TopicHIV Research and Treatment
Canadian institutionsInstitute for Research in Immunology and CancerMcGill UniversityCentre Hospitalier de l’Université de MontréalUniversité de MontréalMcGill University Health Centre
FundersNational Institute of Allergy and Infectious DiseasesNational Institute of General Medical SciencesFonds de Recherche du Québec - SantéCanadian Institutes of Health ResearchNational Cancer InstituteNational Institutes of HealthUniversity of MelbourneCampbell Foundation
KeywordsAntibody-dependent cell-mediated cytotoxicityEpitopeGp41AntibodyBiologyGlycoproteinHuman immunodeficiency virus (HIV)CytotoxicityVirologyCell biologyMolecular biologyImmunologyBiochemistryIn vitroMonoclonal antibody

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.051
Threshold uncertainty score0.998

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.014

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.253
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it