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Record W2937947516 · doi:10.1016/j.jtho.2019.04.008

Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region

2019· article· en· W2937947516 on OpenAlexafffund
Margaret R. Spitz, Richard S. Houlston, Ann G. Schwartz, John K. Field, Jun Ying, Yafang Li, Younghun Han, Xuemei Ji, Wei Chen, Xifeng Wu, Ivan P. Gorlov, Jie Na, Mariza de Andrade, Geoffrey Liu, Yonathan Brhane, Nancy Diao, Angela S. Wenzlaff, Michael P.A. Davies, Triantafillos Liloglou, Maria Timofeeva, Thomas Muley, Hedy S. Rennert, Walid Saliba, Bríd M. Ryan, Elise D. Bowman, J.M. Barros-Dios, Mónica Pérez‐Ríos, Hal Morgenstern, Shanbeh Zienolddiny, Vidar Skaug, Donatella Ugolini, Stefano Bonassi, Erik H.F.M. van der Heijden, Adonina Tardón, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Heike Bickeböller, Susanne M. Arnold, Loı̈c Le Marchand, Olle Melander, Angeline S. Andrew, Kjell Grankvist, Neil E. Caporaso, M. Dawn Teare, Matthew B. Schabath, Melinda C. Aldrich, Lambertus A. Kiemeney, H‐Erich Wichmann, Philip Lazarus, José Mayordomo, Monica Neri, Aage Haugen, Zuo‐Feng Zhang, Alberto Ruano‐Raviña, Hermann Brenner, Curtis C. Harris, Irene Orlow, Gad Rennert, Angela Risch, Paul Brennan, David C. Christiani, Christopher I. Amos, Ping Yang, Olga Y. Gorlova

Bibliographic record

VenueJournal of Thoracic Oncology · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsPrincess Margaret Cancer CentreSinai Health SystemLunenfeld-Tanenbaum Research Institute
FundersNational Institute of Environmental Health SciencesHelmholtz Zentrum MünchenHealth Technology Assessment ProgrammeNational Institutes of HealthInstituto de Salud Carlos IIIXunta de GaliciaBundesamt für StrahlenschutzDeutsche KrebshilfeAssociazione Italiana per la Ricerca sul CancroSheffield Hospitals CharityMinistero della SaluteU.S. Department of Health and Human ServicesDeutscher Akademischer AustauschdienstNational Institute for Health and Care ResearchSociety of Memorial Sloan KetteringJanssen PharmaceuticalsMemorial Sloan-Kettering Cancer CenterNational Cancer InstituteBayerCancer Prevention and Research Institute of TexasAbbVieRoy Castle Lung Cancer FoundationWorld Health OrganizationCanada Research ChairsMedtronicTakeda Pharmaceutical CompanyCanadian Cancer Society Research InstituteRocheDeutsche ForschungsgemeinschaftMerckPrincess Margaret Hospital FoundationBristol-Myers SquibbAstraZenecaPhilips
KeywordsMedicineVariation (astronomy)Descent (aeronautics)Lung cancerLungOncologyCancerInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.017
Threshold uncertainty score0.353

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.334
Teacher spread0.320 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations46
Published2019
Admission routes2
Has abstractno

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