I-102 Viral fitness costs and benefits of disrupting the host cell actin cytoskeleton in mucosal HIV-infection
Bibliographic record
Abstract
HIV-1 disrupts multiple processes that support the motility of infected host cells, including expression and proper localization of chemokine receptors, their downstream signal transduction machinery, and proteins regulating actin cytoskeletal turnover. While models have been developed to explain how these conserved lentiviral activities support HIV replication, their role and relative importance for HIV infection in vivo are largely unexplored. Recently, intravital microscopy studies in advanced humanized mouse models of HIV infection have enabled the visualization of the dynamic behavior of HIV-infected cells in the environmental context of lymphoid tissues, such as spleen and lymph node. Our lab is studying how HIV alters the migratory behavior of HIV-infected T cells in lymph nodes of BLT humanized mice, and how these alterations affect viral replication and persistence. We will present and discuss our recent findings on the roles of the HIV envelope, and the accessory Vpu, and Nef proteins in this context.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".