0825 The Effect of Androgen Deprivation Therapy on Insomnia Symptoms, Fatigue, Mood, and Hot Flashes in Men with Non-Metastatic Prostate Cancer
Bibliographic record
Abstract
Androgen deprivation therapy (ADT) as a treatment for prostate cancer has been associated with sleep problems, mood disturbance, hot flashes, and fatigue, but it is not entirely clear how these factors are associated with each other. The objective of the current study was to examine the impact of ADT on sleep and other symptoms in the first four months of treatment and assess associations among these variables. Men diagnosed with non-metastatic prostate cancer who had not yet begun ADT were eligible. Participants completed the following measures at baseline and four-month follow-up: the Insomnia Severity Index (ISI), the Hot Flash Daily Interference Scale (HFRDIS), the Hospital Anxiety and Depression Scale (HADS) and the Multidimensional Fatigue Symptom Inventory - Short Form (MFSI -SF). Repeated measures t-tests were performed to assess change in symptoms from pre-treatment to four months and correlations were used to describe the relationship between change among variables. The current study consisted of 24 participants, with a mean age of 70 years. At the four-month timepoint, the men reported significant increases in symptoms of insomnia (p=.01, d=0.63), impairment due to hot flashes (p<.001, d=1.48), and fatigue (p<.001, d=1.36), but not anxiety or depressive symptoms. Prior to treatment, only 8% of men reported moderate symptoms of insomnia compared to 21% reporting clinically significant symptoms of insomnia (moderate or severe) at 4-month follow-up. Increases in fatigue, but not insomnia, was significantly associated with increased symptoms of depression (r=.43, p=.04) and anxiety (r=.50, p=.02), and impairment due to hot flashes (r=.62, p=.002) Side effects from ADT present early in treatment. Large effects sizes were observed for insomnia symptoms, hot flashes, and fatigue. Change in fatigue was more strongly associated with mood and hot flashes than insomnia. Data collection is still underway to examine symptom profiles at 8-months and 12-months. Dr. Garland is supported by a New Investigator Award and seed funding from the Beatrice Hunter Cancer Research Institute (BHCRI).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".