MP22-14 DEFINITIVE THERAPY FOR MEN WITH NEWLY-DIAGNOSED OLIGOMETASTATIC PROSTATE CANCER: INITIAL SURGICAL OUTCOMES FROM A PHASE II STUDY
Bibliographic record
Abstract
QoL (WHOQOL-BREF), perception of disease (B-IPQ), symptoms of the disease (QLQ-PR25) and perception of cohesion within the patient-partner relationship (dyadic adjustment, DAS-16).The results are presented as mean Æ standard deviation.The final analysis included 492 patients (74.2 years Æ 8.1), including 470 with a partner evaluation (70.5 Æ 9.0 years).RESULTS: Patient QoL remained mostly stable (0 Æ21.2), while patients' satisfaction with their health improved significantly (6.3 Æ 24.8, p <0.001).The scores of physical (-1.4 Æ 14.5), psychological (-2.3 Æ 13.3) and social (-3.2 Æ 15.9) health were significantly degraded during the study.QoL was significantly deteriorated in patients who had good cohesion in the couple (-4.1Æ19.8)versus medium (2.8Æ19.8)or poor (1.6Æ22.5).A good cohesion in the couple seemed overall an unfavorable factor for the evolution of the scores of QoL, of health and of perception of environment.Associated factors in multivariate analysis with improvement in QoL were: initial presence of symptoms (OR [95% CI]: 3.0 [1.46, 6.17]) and initial low level (2.04 [1.12, 3.72]) or absence of sexual activity (2.23 [1.11, 4.50]).CONCLUSIONS: The men who benefited the most from hormone therapy in terms of QoL were those who suffered from symptoms and those who had no sexual activity at baseline.The influence of the cohesion within the couple on the evolution of the QoL is not confirmed in multivariate analysis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".