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Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial
Ignace Vergote, Giovanni Scambia, David M. O’Malley, Ben Van Calster, Sang‐Yoon Park, Josep M. del Campo, Werner Meier, Aristotelis Bamias, Nicoletta Colombo, Robert M. Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R. Kroep, Haijun Ma, Cheryl A. Pickett, Bradley J. Monk, Sangyoon Park, Yong Sang Song, Yulia Makarova, Joshua Trinidad, Hys Ngan, Gerasimos Aravantinos, Joo‐Hyun Nam, Vera Gorbunova, Л. И. Крикунова, Duk‐Soo Bae, Jóse Ángel Arranz Arija, Claudio Zamagni, Christos N. Papandreou, Francesco Raspagliesi, Alla Lisyanskaya, Ana Oaknin Benzaquen, Germana Tognon, Eugenia Ortega, Joseph Buscema, Andrew Green, Robert A. Burger, Dina Sakaeva, Laurel A. King, Edgar Petru, Ulla Peen, Satoshi Takeuchi, Kimio Ushijima, Antonio González-Martı́n, Scott Kamelle, Michael E. Carney, Frédéric Forget, J. Bentley, Jalid Sehouli, Paolo Zola, Hidenori Kato, Natalya Fadeeva, Evgeny Gotovkin, Vladimir Vladimirov, Eva Guerra Alía, Mark S. Shahin, Snehalkumar M Bhoola, Krishnansu S. Tewari, Daniel M. Anderson, Brigitte Honhon, J. Pelgrims, Amit M. Oza, Jesús García-Donás Jiménez, Vincent Hansen, Ivor Benjamin, Vincent Renard, Heidi Van den Bulck, Claudia Haenle, G. Koumakis, Harushige Yokota, В.М. Попов, William E. Bradley, Robert H. Reid, Donna McNamara, Richard D. Friedman, Joyce N. Barlin, Nicola M. Spirtos, Julia Chapman, P. Sevelda, Manon Huizing, C. Lamot, Frédéric Goffin, Lionel D. Hondt, Allan Covens, Silvana Spadafora, Beate Rautenberg, Toralf Reimer, Volker Möbus, Felix Hilpert, Martina Gropp‐Meier, Antonella Savarese, Sandro Pignata, Francesco Verderame, Mika Mizuno, Hirokuni Takano, Petronella B. Ottevanger, A. Poveda Velasco, Isabel Palacio-Vázquez, Amy Law, Kristi McIntyre, Michael Teneriello, Abbie L. Fields, Samuel S. Lentz, Daron Street, Benjamin J. Schwartz, Robert S. Mannel, Peter Lim, Heather Pulaski, Wolfgang Janni, Andreas Zorr, Ulrich Karck, Ashley Cheng, Roberto Sorio, Cesare Gridelli, Daisuke Aoki, Tetsuro Oishi, Yasuyuki Hirashima, Ingrid Boere, Esther Falcó Ferrer, Patricia S. Braly, Sharon Wilks, Christine Lee, Jeanne M. Schilder, Dan S. Veljovich, Angeles Alvarez Secord, Kevin Davis, Luis Rojas‐Espaillat, Shashikant Lele, Stephen DePasquale, Robert C. Squatrito, Christian Schauer, Luc Dirix, Peter Vuylsteke, E. Joosens, Diane Provencher, Hans-Joachim Lueck, Alexander Hein, Alexander Burges, Ulrich Canzler, Tjoung-Won Park-Simon, Frank Griesinger, Angiolo Gadducci, Oscar Alabiso, Aikou Okamoto, Takashi Sawasaki, Toshiaki Saito, Ana Herrero Ibañez, Coralia Calomeni, Monique A. Spillman, J. K. Choksi, Nicholas F. Taylor, Carolyn Y. Muller, David H. Moore, Paul DiSilvestro, Mary Cunningham, Peter G. Rose, Peter Oppelt, Didier Verhoeven, Marie-Pascale Graas, Prafull Ghatage, Katia Tonkin, Christian Kurzeder, Benjamin Schnappauf, Hannah Schmalzrie, Milena Bruzzone, C. Caballero Díaz, Jerónimo Martínez García, Susana Hernando Polo, Mitchell Garrison, Rodney P. Rocconi, Stephen Andrews, Robert E. Bristow, Michael McHale, Jack Basil, William Houck, Maria C. Bell, Jonathan A. Cosin, Susan C. Modesitt, James E. Kendrick, James L. Wade, Cheung Wong, Anthony C. Evans, Thomas Buekers, Timothy J. Vanderkwaak, J. Stuart Ferriss, Christopher J. Darus, Stacy D. D’Andre, Robert Higgins, Jamie N. Bakkum‐Gamez, Leslie DeMars, Linda Van Le, Larry E. Puls, Shruti Trehan, James P. LaPolla, Elizabeth Dickson Michelson, Joseph Merchant, Christopher G. Peterson, Gary B. Reid, Donald Seago, Susan Zweizig, W Gajewski, Amit Panwalkar, R. Leikermoser, Gerhard Bogner, Philip R. Debruyne, Randal D’hondt, Patrick Berteloot, Joseph Kerger, James Biagi, Vincent Castonguay, Stephen Welch, Aida Muhic, Martin Heubner, Eva‐Maria Grischke, Brigitte Rack, Markus C. Fleisch, Florian Lordick, Dimitrios Pectasides, Wing Ming Ho, Luigi Selvaggi, Flavia Morales Vásquez, William Orlando Brito Villanueva, Alejandro Molina Alavez, Lonneke W. Kessels, César Mendiola Fernández, Miguel Beltrán Fabregat, Salvatore Del Prete, John C. Elkas, G Cecchi, Pallavi Kumar, Warner K. Huh, Mark Messing, Misagh Karimi, Ann Kelley, Babak Edraki, David G. Mutch, Gary S. Leiserowitz, Jeanne E. Anderson, Scott E. Lentz, Setsuko K. Chambers, Robert Morris, Steven Waggoner, Alan N. Gordon, Michael Method, Peter Johnson, Raymond Lord, Janet Drake, K. Sivarajan, Madhu Midathada, Kristen Rice, Troy Wadsworth, James Pavelka, Robert P. Edwards, David S. Miller, Patricia Locantore Ford, Jean Hurteau, David Bender, Veronica Schimp, William Creasman, Rachel E. Lerner, Donald H. Chamberlain, Angela Kueck, John McDonald, Salman Malad, Bernice Robinson-Bennett, Susan A. Davidson, Thomas C. Krivak, Timothy M. Lestingi, Hector Arango, Paul Berard, Karen Finkelstein, Rakesh Gaur, Carolyn Krasner, Frederick R. Ueland, Lance A. Talmage, Seiko Yamada, Gregory P. Sutton, Ronald K. Potkul, Monica Prasad-Hayes, Janet Osborne, Paul Celano, J.T. Thigpen, Sudarshan Sharma, Russell J. Schilder, Jonathan Tammela, M. Margaret Kemeny, Amy Brown, Eric Eisenhauer, James A. Williams, Kendrith M. Rowland, Kenneth Nahum, James Burke, Zahid N Dar, Nicole D. Fleming, Randall K. Gibb, Alfred Guirguis, Thomas J. Herzog, Veena S. John, Santhosh Kumar, Aparna A. Kamat, Mohamad Kassar, Mario M. Leitão, Lyuba Levine, Luis Mendez, Dhimant Patel, Emily Berry, David Warshal, Judith K. Wolf, Corrine Zarwan, Yvonne Collins, Gary Spitzer, Brigitte Miller, Mark H. Einstein
Bibliographic record
VenueThe Lancet Oncology · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAngiogenesis and VEGF in Cancer
Canadian institutionsUniversity of TorontoSunnybrook Health Science Centre
FundersCilagGenentechF. Hoffmann-La RocheRocheMerckAmgen
KeywordsMedicineClinical endpointOvarian cancerCarboplatinPopulationProgression-free survivalInternal medicinePlaceboOncologyPhases of clinical researchClinical trialGynecologyCancerChemotherapyPathology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.342
Threshold uncertainty score0.898
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.083
GPT teacher head0.401
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations86
Published2019
Admission routes1
Has abstractno