O-10 (11:50 to 12:02): Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia
Bibliographic record
Abstract
To study the prevalence of Barrett esophagus (BE) (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia (EA). This multicentric, prospective study included patients 15 to 19 year-old with medical history of EA. An upper endoscopy with standardized esophageal staged biopsies (at least 12) under general anesthesia was performed. Histological suspicion of metaplasia benefited from a centralized confirmation. 120 patients aged 16.5 years (Â ± 1.4) were included. At evaluation, 8% had denutrition, 41% had an anti-reflux surgery performed and 41% had GERD symptoms with only 28% under medical treatment. Esophagitis was found at endoscopy in 34% and confirmed at histology in 67%. Endoscopy suspected BE in 37%, confirmed at histology in 43% (50 gastric and 1 intestinal). No endoscopic nor histological anomalies were found at the anastomosis. No significant relationships were found between BE and clinical symptoms. Multivariate analysis showed that BE was associated to EA without fistula (p = 0.03; OR = 0.21 [0.05–0.87]); previous multiple antireflux surgery (p = 0.04; OR = 3.29 [1.08–10.07]); BE suspicion at endoscopy (p < 0.001; OR = 0.04 [0.01–0.18]); histological esophagitis (p = 0.02; OR = 0.17 [0.04–0.73]). Patients with EA are at high risk of persistent GERD and BE. Long-time systematic follow-up of the esophageal mucosa including multistaged biopsies is therefore required even in asymptomatic patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".