305 CHYLOTHORAX IN AN INFANT WITH FEATURES OF PETERS PLUS SYNDROME.
Bibliographic record
Abstract
Peters Plus syndrome is a rare autosomal recessive condition associated with anterior eye chamber anomalies, disproportionate short stature, and developmental delay. There are characteristic facial features and increased rates of cardiac and renal malformations. We describe a case of a premature male infant with clinical features of Peters Plus syndrome, born to nonconsanguinous parents. There were prenatally detected bilateral nonimmune chylothoraces and ascites of unknown etiology. Postnatal findings included an anterior chamber defect of the right eye, bilateral preauricular ear pits, short midface, anteverted nares, prominent cupid9s bow of the upper lip, and a single umbilical artery. Echocardiography identified an enlarged right atrium and ventricle, a large patent ductus arteriosus, atrial septal defect, and poor global cardiac function. Bilateral cystic dysplastic kidneys were seen on a sonogram at birth. The course was complicated by pulmonary hypertension, respiratory failure requiring continuous ventilator support, impaired renal function, and persistent hydrops. The infant died at a corrected gestational age of 40 weeks from kidney and cardiac failure. Postmortem autopsy revealed extensive subendocardial right ventricular calcification, focal glomerulocystic changes of the kidneys, and disproportionately short limb measurements. Karyotyping and subtelomeric fluorescence in situ hybridization (FISH) were normal. A family history of Wilms9 tumor prompted FISH analysis for PAX6 and WT1 with no evidence of microdeletion. Chylothorax has not previously been described in association with Peters Plus syndrome and may represent an additional clinical manifestation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".