Oral Abstracts (Abstracts 1–299)
Bibliographic record
Abstract
Background: Surgeons frequently reject high-risk donor livers, which currently comprise the only increasing and underutilised donor resource. The VITTAL trial assessed "transplantability" of discarded livers with NMP and evaluated 90-day outcomes in these grafts. Methods: This prospective, single-arm phase 2 trial included deceased donor livers, discarded by all UK centres, that met at least one of the following criteria (donor risk index 2.0, macrosteatosis 30%, ALT/AST 1000IU/mL, donor WIT 30mins in DCD livers, poor perfusion or anticipated CIT 12 for DBD or 8hrs for DCD livers. Recipients included consented adults undergoing primary transplantation, with a UKELD score 62, without portal vein thrombosis or significant cardiovascular comorbidity. Livers clearing lactate to 2.5mmol/L within 4 hours of NMP and meeting two other criteria (good arterial/ venous flow, bile production, homogenous perfusion, pH improvement) were deemed transplantable. The primary endpoints were liver salvage success rate and recipient 90day survival. Results: Over 15 months, 185 retrieved livers were discarded for clinical use (Figure Donor inclusion criteria were not met in 25, 21 were offered when the NMP machine was being used, and there were no suitable recipients for 41. Thirty-one livers (14 DCD) were included in the trial. Donor age was 57yrs(30-84), BMI 29kg/ m 2 (20-42), DRI 2.2(1.2-3.8), liver weight 1.8kg(1.2-2.6) and the CIT was 7.33hrs(5:17-14:50) [median (range)]. Of these, 22(71%) livers were transplanted after meeting viability criteria. The total preservation time was 17:53hrs(11:21-25:32). Patient and graft 90-day survival were 100%. Seven (32%) patients developed early allograft dysfunction, and 5(23%) patients developed Clavien-Dindo complication grade 3, including 4(18%) cases with acute kidney injury requiring renal replacement therapy. The median intensive care and in-hospital stay were 3 days (2-39) and 10 days (6-47) respectively. Conclusion: Viability testing of discarded livers with NMP is feasible and predicts early post-transplant function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".