Looking beyond cancer for cabozantinib-induced cardiotoxicity: evidence of absence or absence of evidence?
Bibliographic record
Abstract
The advent of molecular targeted therapy has transformed the scape of medical oncology in the past decades—patients previously deemed terminal now have more treatment options proven to extend survival. An example is renal cell carcinoma (RCC); given its myriad clinical presentation, a significant proportion of patients have locally advanced or metastatic disease at the time of diagnosis. Historically, treatment options for such patients were limited and their prognosis grim. In the past years, however, vascular endothelial growth factor (VEGF) inhibitors and tyrosine kinase inhibitors (TKIs), such as bevacizumab, sunitinib and pazopanib, have been shown to improve progression-free survival, although there have been increasing reports of drug cardiotoxicity including hypertension and heart failure (1-5). As a result, there is a growing need for better patient selection, prevention and monitoring of cardiotoxicity during treatment, as well as exploration of alternative safer agents.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".