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Record W2950081290 · doi:10.1016/j.nbd.2019.04.004

Heritability and genetic variance of dementia with Lewy bodies

2019· article· en· W2950081290 on OpenAlexaff
Rita Guerreiro, Valentina Escott‐Price, Dena Hernandez, Célia Kun‐Rodrigues, Owen A. Ross, Tatiana Orme, João Luís Neto, Susana Carmona, Nadia Dehghani, John D. Eicher, Claire E. Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, Juan C. Troncoso, Olga Pletnikova, Ted M. Dawson, Liana S. Rosenthal, Olaf Ansorge, Jordi Clarimón, Alberto Lleó, Estrella Morenas‐Rodríguez, Lorraine N. Clark, Lawrence S. Honig, Karen Marder, Afina W. Lemstra, Ekaterina Rogaeva, Peter St George‐Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al‐Sarraj, Tammaryn Lashley, Janice L. Holton, Yaroslau Compta, Vivianna M. Van Deerlin, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Mónica Díez-Fairén, Miquel Aguilar, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamás Révész, Andrew J. Lees, Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Caroline Graff, Nigel J. Cairns, John C. Morris, Stuart Pickering‐Brown, David Mann, Glenda M. Halliday, John Hardy, John Q. Trojanowski, Dennis W. Dickson, Andrew Singleton, David J. Stone, José Brás

Bibliographic record

VenueNeurobiology of Disease · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsOccupational Cancer Research CentreCanada Research ChairsUniversity of Toronto
FundersNational Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institute on Drug AbuseFogarty International CenterNational Heart, Lung, and Blood InstituteMedical Research CouncilNational Center for Advancing Translational SciencesNational Human Genome Research InstituteNIHR Oxford Biomedical Research CentreAlzheimer's SocietyWellcome TrustAgence Nationale de la RechercheParkinson's UKNational Institutes of HealthNational Institute on AgingParkinson's Disease FoundationBRACEMichael J. Fox Foundation for Parkinson's ResearchAlzheimer's Research TrustRosetrees Trust
KeywordsHeritabilityGenome-wide association studyDementia with Lewy bodiesBiologyLinkage disequilibriumGenetic correlationGenetic variationGeneticsSingle-nucleotide polymorphismGenetic associationGenetic architectureSNPDiseaseParkinson's diseaseAlleleMissing heritability problemDementiaPhenotypeEvolutionary biologyGenotypeMedicineGenePathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.007
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.214
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2019
Admission routes1
Has abstractno

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