PB2213 SPLANCHNIC VEIN THROMBOSIS IN MYELOPROLOFERATIVE NEOPLASMS; A PROSPECTIVE ANALYSIS OF THROMBOSIS OUTCOME
Bibliographic record
Abstract
Background: Splanchnic vein thrombosis (SVT) includes extrahepatic portal vein obstruction (EHPVO), Budd‐Chiari syndrome (BCS) and mesenteric vein thrombosis. Myeloproliferative neoplasms (MPN) account for the majority of non‐cirrhotic SVT and are diagnosed in 30% of patients with EHPVO and 40% with BCS. SVT in MPN patients is associated with significant morbidity and mortality. There have been no prospective studies looking at this subset and there is very little in the way of guidance in managing this complex patient group. Aims: MASCOT is a prospective observational longitudinal study of patients with MPN related splanchnic vein thrombosis. The primary end points of the study are to describe morbidity/portal circulation in the patient group over 18‐24months from baseline, assess any changes in end points clinically and radiologically. Methods: 29 patients from two centres were recruited and followed up for 24 months. Radiological primary endpoints, examined changes in initial thrombus, including thrombus extension or recurrence, recanalization in patients without cavernoma and changes in spleen size. Results: The male: female (M:F) was 13:16 with an average age of 48 years (25‐72). The majority of patients had an underlying diagnosis of polycythaemia vera (PV) 13 (45%), followed by essential thrombocythaemia (ET) 9 (31%) and the remaining patients had primary myelofibrosis (PMF), MPN‐unclassified (MPN‐U), post essential thrombocytosis‐MF (PET‐MF). Two patients did not have evidence of MPN on bone marrow histology. 27/29 had the JAK2v617f mutation; 2 had CALR mutation. Summary/Conclusion: In this prospective study of patients we did not observe recurrence or extension of SVT, however a small proportion of patients went on to develop further thrombotic complications whilst on anticoagulation. The study aims to follow patients for duration of five years with repeat imaging and clinical data.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".