Impacts of Early Life Adversity on Microbiota and Immune Functioning in Individuals with Major Depressive Disorder
Bibliographic record
Abstract
Early life stress may contribute to depression vulnerability, possibly through immune system development and gut microbial colonization patterns.Increased pro-inflammatory cytokines and differences in gut microbiota composition have been seen in depressed individuals.The current study investigated inflammatory and bacterial profiles of 39 individuals with a current major depressive episode and 43 healthy volunteers with varying severity of childhood trauma.Plasma interleukin (IL)-6/IL-10 ratios was positively correlated with depression severity, and childhood trauma explained variance in severity of symptoms above and beyond that accounted for by the IL-6/IL-10 ratios.Expression of Faecalibacterium prausnitzi (F.prausnitzi) in stool was decreased in depressed participants compared to healthy controls.Importantly, this relationship was significant only in participants who had experienced moderateto-severe physical neglect.These findings suggest a relationship between particular gut bacteria and depressive symptoms that is dependent on the presence of specific types of early life trauma.Table of Contents Abstract……………………………………………………………………………………… Acknowledgements………………………………………………………………………….. List of Abbreviations………………………………………………………………………… List of Tables/Figures………………………………………………………………………... List of Appendices…………………………………………………………………………… Introduction………………………………………………………………………………….Early Life Trauma and Depression……………………………………..…………….Inflammatory Measures Implicated in Depression Vulnerability and Severity……… Microbiome Alterations Implicated in Depression Vulnerability and Severity……... Goals and Hypotheses of Current Study……………………………………………... Materials and Methods……………………………………………………………………….. Participants…………………………………………………………………………… Experimental Design……………………………………………………………….… Experimental Procedures and Materials………………………………………….….. Statistical Analyses…………………………………………………………………... Results…………………………………………………………………………………….….. Demographics and Diet……………………………………………………………… Psychological Measures……………………………………………………………… Group comparison of inflammation/bacterial profiles ………………………….……Inflammation/bacterial/psychological measure relationships…………………..…….
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".