The Effect Of Exercise Training And Increasing Non-exercise Physical Activity On Glyca Levels
Bibliographic record
Abstract
PURPOSE: Aerobic training has been shown to have a beneficial effect on GlycA, which is a marker of inflammation. However, it has not been previously reported if an intervention with aerobic training and increasing non-exercise physical activity can further reduce GlycA. Thus, the purpose of the present study is to determine the impact of the combination of aerobic training and increasing non-exercise physical activity on GlycA levels compared to aerobic training alone in obese adults. METHODS: Obese adults (N=30) were randomized to an aerobic training, (AERO), aerobic training and increasing non-exercise physical activity, (AERO-PA) or a control (CON) group for 6 months. Both exercise groups performed supervised aerobic training (50%-75% VO2 max) at a dose of 12 kcals per kg per week. Along with exercise training, the AERO-PA group had the goal of increasing non-exercise physical activity ~3,000 steps above baseline levels. Archived blood samples were obtained at baseline and at follow-up and subsequently analyzed by LipoScience for GlycA after the completion of the study (LabCorp, Morrisville, NC). An ANCOVA was used to evaluate the change in GlycA across the intervention groups with adjustment for the baseline value. Person correlations were run to evaluate the change in GlycA with weight, body composition, and fitness variables. RESULTS: Significant within groups reductions in GlycA were observed in the AERO (-43.1 μmol/L, CI:-74.1 to -12.2) and the AERO-PA groups (-31.2 μmol/L, CI: -61.2 to -1.1), but this change was not significant compared to the CON group (-15.4 μmol/L, CI: -41.8 to 11.0). The change in GlycA in exercisers was not associated with the change in fitness (r=-0.18, p=0.47), waist circumference (r=-0.37 p=0.13), weight (r=-0.31, p=0.21), body fat (r=-0.28, p=0.26) or change in steps of non-exercise physical activity (r=0.35, p=0.16). CONCLUSION: Neither aerobic exercise training or aerobic training and increasing non-exercise physical activity reduced inflammation levels in obese adults measured by GlycA. Changes in GlycA are not associated with body composition, non-exercise physical activity, or fitness changes associated with aerobic exercise training.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".