EBV infection is associated with histone bivalent switch modifications in squamous epithelial cells
Bibliographic record
Abstract
Significance Epstein−Barr virus (EBV) infection is implicated in the development of certain cancers; however, the mechanisms by which EBV contributes to the pathogenesis of epithelial cell malignancies remains unclear. This study highlights the association of EBV infection with aberrant modifications in histone bivalent marks, H3K4me3 and H3K27me3, in nasopharyngeal epithelial cells. Down-regulation of the DNA damage repair pathway genes, including MLH1 , associated with aberrant histone bivalent marks in a promoter hypermethylation-independent manner, was observed after EBV infection. This finding provides strong evidence linking EBV infection to epigenetic modifications in epithelial cells. This study also suggests that the level of MLH1 may be useful as a potential biomarker to evaluate the responsiveness of nasopharyngeal carcinoma patients to cisplatin-based therapies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".