Effects of mechano-electrical feedback on the onset of alternans: A computational study
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Bibliographic record
Abstract
Cardiac alternans is a heart rhythm instability that is associated with cardiac arrhythmias and may lead to sudden cardiac death. The onset of this instability, which is linked to period-doubling bifurcation and may be a route to chaos, is of particular interest. Mechano-electric feedback depicts the effects of tissue deformation on cardiac excitation. The main effect of mechano-electric feedback is delivered via the so-called stretch-activated ion channels and is caused by stretch-activated currents. Mechano-electric feedback, which is believed to have proarrhythmic and antiarrhythmic effects on cardiac electrophysiology, affects the action potential duration in a manner dependent on cycle length, but the mechanisms by which this occurs remain to be elucidated. In this study, a biophysically detailed electromechanical model of cardiac tissue is employed to show how a stretch-activated current can affect the action potential duration at cellular and tissue levels, illustrating its effects on the onset of alternans. Also, using a two-dimensional iterated map that incorporates stretch-activated current effects, we apply linear stability analysis to study the stability of the bifurcation. We show that alternans bifurcation can be prevented depending on the strength of the stretch-activated current.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it