MétaCan
Menu
Back to cohort
Record W2955852147 · doi:10.1016/j.bmcl.2019.06.021

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

2019· article· en· W2955852147 on OpenAlexaff
Sarah M. Bronner, Karl A. Merrick, Jeremy Murray, Laurent Salphati, John G. Moffat, Jodie Pang, Christopher J. Sneeringer, Nicholas Dompe, Patrick Cyr, Hans E. Purkey, Gladys de Leon Boenig, Jun Li, Aleksandr Kolesnikov, Robin Larouche‐Gauthier, Kwong Wah Lai, Xiaoli Shen, Samuel Aubert‐Nicol, Yi‐Chen Chen, Jonathan Cheong, James J. Crawford, Marc Hafner, Pouyan Haghshenas, Araz Jakalian, Jean‐Philippe Leclerc, Ngiap‐Kie Lim, Emile G. Plise, Hadil Shalan, Claudio F. Sturino, John Wai, Yang Xiao, Jianping Yin, Liang Zhao, Stephen E. Gould, Alan G. Olivero, Timothy P. Heffron

Bibliographic record

VenueBioorganic & Medicinal Chemistry Letters · 2019
Typearticle
Languageen
FieldMedicine
TopicAdvanced Breast Cancer Therapies
Canadian institutionsParaza Pharma (Canada)
FundersSLAC National Accelerator LaboratoryBiological and Environmental ResearchBasic Energy SciencesNational Institute of General Medical SciencesGenentechOffice of ScienceNational Institutes of HealthU.S. Department of Energy
KeywordsCyclin-dependent kinase 6ChemistryPalbociclibPolar surface areaPharmacologyCell cycleCyclin-dependent kinase 1KinaseCancer researchPotencyCyclin-dependent kinaseBiochemistryCellCancerInternal medicineIn vitroBiologyBreast cancerMedicineMetastatic breast cancer

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.247
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations64
Published2019
Admission routes1
Has abstractno

Explore more

Same venueBioorganic & Medicinal Chemistry LettersSame topicAdvanced Breast Cancer TherapiesFrench-language works237,207