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Record W2955874948 · doi:10.1016/s1474-4422(19)30137-1

Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial

2019· article· en· W2955874948 on OpenAlex
Diego Cadavid, Michelle Mellion, Raymond Hupperts, Keith R. Edwards, Peter A. Calabresi, Jelena Drulović, Gavin Giovannoni, Hans‐Peter Hartung, Douglas L. Arnold, Elizabeth Fisher, Richard A. Rudick, Sha Mi, Yi Chai, Jie Li, Yiwei Zhang, Wenting Cheng, Lei Xu, Bing Zhu, Susan M Green, Ih Chang, Aaron Deykin, Sarah Sheikh, Eduardo Agüera, Abdullatif Al Khedr, Radek Ampapa, Rafael Arroyo, Martin Belkin, Robert Bonek, Alexey Boyко, Ruggero Capra, Diego Centonze, Pierre Clavelou, Marc Debouverie, Nikos Evangelou, E. P. Evdoshenko, Óscar Fernández, Victoria Fernández Sánchez, Mark Freedman, Steven Freedman, Waldemar Fryze, Antonio Garcı́a-Merino, Mira Gavric-Kezic, Angel Ghezzi, Olivier Gout, Luigi M.E. Grimaldi, Barry Hendin, Hanka Hertmanowska, Rogier Hintzen, Pavel Hradílek, Jan Ilkowski, Evelina Ivashinenkova, Guillermo Izquierdo, François Jacques, Gábor Jakab, Ф. А. Хабиров, Gabriela Kłodowska-Duda, S. Komoly, Smiljana Kostić, Ivana Kovářová, Marcelo Kremenchuzky, Christopher LaGanke, Yves Lapierre, Maciej Maciejowski, Francois Grand’ Maison, Girolama Alessandra Marfia, Sergio Martínez‐Yélamos, Eva Meluzínová, Xavier Montalbán, Ronald S. Murray, Robert T. Naismith, Scott D. Newsome, Viet‐Anh Nguyen, Delia Oreja, Gabriel Pardo, Elena S. Pasechnik, Francesco Patti, Andrzej Potemkowski, С. В. Прокопенко, Peiqing Qian, Alfredo Rodríguez Antigüedad, Howard Rossman, Csilla Rózsa, Fernando Sánchez López, Krzysztof Selmaj, Eli Silber, Adam Stępień, Anna Stepniewska, Maciej Świat, Gordana Tončev, Ayman Tourbah, Tatyana Trushnikova, Antonio Uccelli, Marta Vachová, Martin Vališ, László Vécsei, Sandrine Wiertlewski, Mauro Zaffaroni, Tomasz Zieliński

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueThe Lancet Neurology · 2019
Typearticle
Languageen
FieldMedicine
TopicMultiple Sclerosis Research Studies
Canadian institutionsNeuroRx Research (Canada)Montreal Neurological Institute and Hospital
FundersAcorda TherapeuticsCelgeneBiogen
KeywordsPlaceboMultiple sclerosisMedicinePhase (matter)Internal medicinePhysical therapyAlternative medicinePsychiatryChemistryPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.175
Threshold uncertainty score0.434

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.289
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it