Aqueous Cytokines in Sympathetic Ophthalmia Following Complications of Intravitreal Aflibercept
Bibliographic record
Abstract
Purpose: This article reports a case of sympathetic ophthalmia (SO) following complications from bilateral intravitreal aflibercept injections, including infectious endophthalmitis requiring vitreoretinal surgery in the left eye (OS) and sterile intraocular inflammation in the right eye (OD), and describes the aqueous cytokine profile of this patient. Methods: The patient was a 51-year-old man with SO. Cytokine levels in the aqueous humor of the sympathizing eye were measured at presentation. Results: A patient being treated with bilateral aflibercept injections for diabetic macular edema developed infectious endophthalmitis OS requiring a pars plana vitrectomy and sterile intraocular inflammation OD, which subsequently led to SO. Enucleation of the exciting eye (OS) was performed and histopathology confirmed the diagnosis. Cytokine levels in the sympathizing eye revealed high concentrations of intercellular adhesion molecule-1, inducible protein-10, and interleukin-8 and -10. Conclusions: SO can occur after vitreoretinal surgery for endophthalmitis in the exciting eye and sterile intraocular inflammation in the sympathizing eye following aflibercept injections.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".