Transcranial Magnetic and Electrical Stimulation in Alzheimer's Disease and Mild Cognitive Impairment: A Review of Randomized Controlled Trials
Bibliographic record
Abstract
Alzheimer's disease (AD) and related dementia is an immense personal and public health burden. Available treatments have modest efficacy in reducing symptoms of AD and have no significant impact on the course of the illness. Moreover, attempts to discover novel treatments have to date failed. Noninvasive brain stimulation comprises a suite of interventions that are based on transcranial magnetic or electric stimulation of different brain regions. Promising findings are emerging from two forms of noninvasive brain stimulation: repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Here, the results from the randomized controlled trials (RCTs) that assessed rTMS or tDCS in AD or in mild cognitive impairment, a clinical state that typically preceded AD, are reviewed. Overall, there are few RCTs, and most of them are limited by small sample sizes. Larger RCTs and additional research are needed to identify the best stimulation parameters for these two interventions.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.017 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".