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Record W2966095247 · doi:10.1016/j.dadm.2019.04.010

European Ultrahigh‐Field Imaging Network for Neurodegenerative Diseases (EUFIND)

2019· article· en· W2966095247 on OpenAlexaff
Emrah Düzel, Julio Acosta‐Cabronero, David Berron, Geert Jan Biessels, Isabella M. Björkman‐Burtscher, Michel Bottlaender, Richard Bowtell, Mark A. van Buchem, Arturo Cárdenas‐Blanco, Fawzi Boumezbeur, Dennis Chan, Stuart Clare, Mauro Costagli, Ludovic de Rochefort, Ariane Fillmer, Penny Gowland, Oskar Hansson, Jeroen Hendrikse, Oliver Kraff, Mark E. Ladd, Itamar Ronen, Esben Thade Petersen, James B. Rowe, Hartwig R. Siebner, Tony Stoecker, Sina Straub, Michela Tosetti, Kâmil Uludaǧ, Alexandre Vignaud, Jaco J.M. Zwanenburg, Oliver Speck

Bibliographic record

VenueAlzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2019
Typearticle
Languageen
FieldMedicine
TopicAdvanced MRI Techniques and Applications
Canadian institutionsUniversity Health Network
FundersMedical Research CouncilAix-Marseille UniversitéHorizon 2020 Framework ProgrammeNovo Nordisk FondenEU Joint Programme – Neurodegenerative Disease ResearchLundbeckfondenBundesministerium für Bildung und ForschungWellcome TrustNederlandse Organisatie voor Wetenschappelijk OnderzoekAgence Nationale de la RechercheDeutsche ForschungsgemeinschaftEuropean Commission
KeywordsMedicineNeuroscienceField (mathematics)PsychologyMathematics

Abstract

fetched live from OpenAlex

INTRODUCTION: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. METHODS: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. RESULTS: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. DISCUSSION: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.040
metaresearch head score (Gemma)0.020
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.040
Threshold uncertainty score0.211

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0400.020
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0010.001
Scholarly communication0.0030.003
Open science0.0050.008
Research integrity0.0040.002
Insufficient payload (model declined to judge)0.0190.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.341
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations35
Published2019
Admission routes1
Has abstractyes

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