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Record W2968728756 · doi:10.1111/andr.12697

A new era in research on the epididymis

2019· editorial· en· W2968728756 on OpenAlex
Bernard Robaire

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueAndrology · 2019
Typeeditorial
Languageen
FieldMedicine
TopicSperm and Testicular Function
Canadian institutionsMcGill University
Fundersnot available
KeywordsEpididymisChinaMesonephric ductHonorSpermPolitical scienceMedicinePhysiologyAndrologyInternal medicineLawKidney

Abstract

fetched live from OpenAlex

After meetings in Hong Kong, Robertson (Australia), Charlottesville (Virginia), Chatel-Guyon (France), Sao Palo (Brazil), and Shanghai (China), the 7th International Conference on the Epididymis was held in Montreal (Canada) from September 20 to 23, 2018. One hundred scientists from 11 countries gathered to present their most recent findings on this critically important tissue in male reproduction, one that has received far less attention than it deserves. Special presentations were made to honor two of the founding ‘parents’ of our modern understanding of the epididymis (Fig. 1). The Plenary lecture, named after Dr. Marie-Claire Orgebin-Crist, was delivered by Dr. Louis Hermo. Dr. Patricia Cuasnicu presented the remarkable achievements of Dr. Michael Bedford, who passed away earlier in 2018. We are fortunate to have a picture of these two pioneers that was taken at the previous Conference on the Epididymis. The outstanding suggestions from members of the Program Committee (Avellar MC—Brazil, Breton S—USA, Cornwall G—USA, Cuasnicu P—Argentina, Drevet J—France, Hinton BT—USA, Robaire B—Canada, and Zhang Y—China) allowed us to bring together leaders researching every facet of ‘the tissue’. The main themes of the meeting were as follows: development of the Wolffian duct and the epididymis; physiology of the epididymis; epididymal sperm maturation and contraception; non-coding RNAs in the epididymis; infections of and defense by the epididymis; immune system and the epididymis; toxicants and epididymal function; the human epididymis; and clinical aspects of epididymal dysfunction. Excellent presentations were provided by 22 invited speakers and in 51 posters, covering a remarkably rich variety of novel and exciting developments regarding our understanding of how this tissue functions and is regulated. A PDF of the program and of abstracts may be found at: http://www.medicine.mcgill.ca/pharma/robairelab/Documents/Epididymis7_FinalProgram.pdf This issue of Andrology contains 19 articles, representing nearly 90% of the presentations delivered by invited speakers. Each of these peer-reviewed articles contributes new dimensions to our understanding of the complexity of this remarkably long tube that creates and provides continuously changing environments for spermatozoa as they mature and are then stored. The dynamic interactions with the immune system, the interface between the epithelial cells and spermatozoa via epididymosomes, our evolving understanding of the roles of non-coding RNAs and other small molecules, are all opening new avenues that are likely to provide new opportunities for the development of male contraceptives and the treatment of male infertility. The success of this meeting would not have been possible without the untiring efforts of Ms. Elise Boivin-Ford and Dr. Anais Noblanc and the financial contributions from the Male Contraceptive Initiative, Canadian Institutes for Health Research, Society for the Study of Reproduction, American Society of Andrology, International Society of Andrology, Reseau Quebecois en Reproduction, McGill University, McGill University Health Centre, Centre for Research in Reproduction and Development, Université de Montréal, Université Laval, Institut National de Recherche en Santé, and Fluxion.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.014
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.083
GPT teacher head0.394
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it