Additive effect of selenium and bicalutamide in human prostate cancer cells in vitro
Bibliographic record
Abstract
3835 Introduction: Prostate cancer (PCa) is the commonest non-cutaneous malignancy and second leading cause of cancer death in males. Evidence from epidemiological and clinical trials indicates that selenium may reduce the risk of PCa. To date, selenium has not been shown to offer a therapeutic benefit in the management of established prostate cancer. We hypothesize that a combination of selenium and bicalutamide could lead to delayed androgen resistance, providing additional therapeutic benefit for the management of advanced PCa. Methods: Human PCa cells {LNCaP and PC3-AR2 (AR positive) and PC3-M (AR negative)} were incubated for 72 h with, varying concentrations of seleneno-DLmethionine (0-200 μM), bicalutamide (0-100 μM) or a combination of both. Cells were fixed and stained with propidium iodide for flow cytometric analysis. Cellular protein and DNA were extracted to determine expression of apoptotic markers. The individual and combined effects of these compounds on cell proliferation were assessed by MTT assay. Results: Data obtained from flow-cytometric analysis demonstrate that significant apoptosis (p
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".