P3A.09: Physical activity, strength and fatigue in children with intestinal failure on parenteral nutrition
Bibliographic record
Abstract
Introduction: With improved survival of children with intestinal failure (IF), it is important to explore the subsequent impact on long-term physical function. This study evaluates functional outcomes of muscle strength, fatigue and physical activity (PA) and identifies clinical factors that may be predictive of impairment. Methods: Cross-sectional study in children with IF on long term parenteral nutrition (PN) compared to healthy age and gender matched controls (HC’s). Assessments included: Bruininks-Oseretsky Test of Motor Proficiency-2 (Strength and Agility subtest) (BOT-2), Grip strength, Paediatric Quality of Life (PedsQL) Physical Function subscale and Multi-Dimensional Fatigue Module, and Benefits/Barriers to PA Questionnaire. PA was measured using an accelerometer. Medical data was collected by chart abstraction. Results: Participants included 21 children with IF (14 male) at a median age of 8.33 (IQR 6.96, 11.04) years and 33 HC’s (20 males), 8.25 (6.67, 10.79) years. In those with IF, 13 (62%) were born prematurely (gestational age 35 (33, 38.5) weeks) and the most common diagnosis was gastroschisis (38%). Children received PN for 14 (11, 16) hours/day, with 17 (81%) dependent since infancy. Since birth, there was a median of 4 (1, 9) septic episodes and 15 (7.5, 24.5) in-patient hospitalizations. Mean BOT-2 standard scores [population norm of 50, SD of 10] were 61.27 +/- 6.8 for HC’s and 45.67 +/- 9.1 for children with IF, with 6/21 (28%) below average (>1SD below mean). 13/21 (62%) children fell >1SD below the mean norm for grip strength, compared to only 6/33 (18.2%) HC’s. Mean steps/day in children with IF was 9842 +/- 4077 compared to HC’s with 13104 +/- 5416. There was a significant difference between groups in strength and agility (p<.001), grip strength (p=.001), and total steps/day (p=.047). Medical variables significantly associated with BOT-2 scores are shown in Table 1. Results of the PedsQL are shown in Figure 1. Parents report greater fatigue (r=-.538, p=.012) and poorer physical function (r=-.650, p=.001) in children with more hospitalizations. Barriers to PA in children with IF included “I am tired” and “I am worried about my line.” Conclusion: Factors such as prematurity, decreased linear growth, hospitalization and septic events may have a significant impact on physical function outcomes in children with IF on PN. Ongoing development of medical and rehabilitation intervention strategies is vital to optimize outcomes.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".