Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.276 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
These results suggest that sTREM2 is associated with attenuated cognitive and clinical decline, a finding with important implications for future clinical trials targeting the innate immune response in AD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Science Translational Medicine
- Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- Canadian Institutes of Health ResearchNational Institutes of HealthGenentechNational Institute of Neurological Disorders and StrokeIXICOH. Lundbeck A/SServierEisaiDeutsche ForschungsgemeinschaftNorthern California Institute for Research and EducationF. Hoffmann-La RocheUniversity of Southern CaliforniaPfizerBioClinicaBiogenU.S. Department of DefenseEli Lilly and CompanyBristol-Myers SquibbNovartis Pharmaceuticals CorporationMeso Scale DiagnosticsCure Alzheimer's FundJanssen Alzheimer Immunotherapy Research And DevelopmentEuropean CommissionNational Institute on AgingAlzheimer's Association
- Keywords
- Cognitive declineCerebrospinal fluidTREM2DiseaseMedicineAlzheimer's diseaseInternal medicineCognitionDementiaNeurosciencePsychologyPsychiatryMicrogliaInflammation
- Has abstract in OpenAlex
- yes