Hyperprogressive disease with immunotherapy: new directions
Bibliographic record
Abstract
The phenomenon of hyperprogression and its association with the use of immune checkpoint inhibitors (ICIs) has been increasingly described in recent literature. However, hyperprogressive disease (HPD) as a unique growth pattern remains controversial. HPD can be defined as the sudden acceleration of tumor growth kinetics above its baseline growth rate. The tumor genome is inherently unstable and changes affecting crucial mechanisms of cell growth can result in unexpeted changes in growth patterns. Small cell transformation in oncogene addicted cancers is an example of such sudden change. The point of contention with HPD is whether it is truly acceleration of growth caused by ICI exposure or simply a failure of antitumor efficacy (i.e., the tumor’s natural history). As ICIs move into the frontline treatment of several different cancer types, it is important to understand this phenomenon in order to avoid causing harm.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.009 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.006 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.011 | 0.022 |
| Insufficient payload (model declined to judge) | 0.006 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".