Pediatric Reference Intervals for the DxH 520* Hematology Analyzer
Bibliographic record
Abstract
Abstract Introduction: The DxH 520 is a small hematology analyzer capable of performing CBC and 5-part differential in fresh whole blood samples (venous and capillary) collected in K2EDTA and K3EDTA anticoagulants. Medical care of children and adolescents is significantly dependent on reference intervals to properly interpret laboratory test results. A multi-center study was performed to verify or establish pediatric reference intervals for all parameters (White Blood Cells (WBC), Red Blood Cells (RBC), Hemoglobin (Hgb), Hematocrit (Hct), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Distribution Width (RDW), RDW-SD, Platelets (PLT), Mean Platelet Volume (MPV), (Lymphocyte) LY%, LY#, Monocyte% (MO%), MO#, Neutrophil % (NE%), NE#, Eosinophil% (EO%), EO#, Basophil % (BA%), and BA#) with combined genders. Methods: Whole blood samples from healthy children were tested within 8 hours of collection on the DxH 520 analyzer. Samples generating review flags or suspect messages were excluded from the analyses. Even gender distribution was targeted. A total of 208 specimens were enrolled that included 20 neonates (0 to 30 days), 27 infants (31 days to 2 years), 94 children (3 to 12 years) and 67 adolescents (13 to 21 years). Results were analyzed according to CLSI EP20-A3c guidelines. Results: Reference intervals for the neonate age group were verified from existing published ranges using the transference method described in the guideline (Table 1). The robust method was used to calculate two sets of reference intervals partitioned by combining data from the infant and children age groups, and from the adolescent age group (Table 2). Conclusion: Reference Intervals for CBC and differential parameters have been established for pediatric age groups (0 to 30 days, 31days to 12 years, 13 to 21 years) on the DxH 520 Hematology analyzer. *CE marked. Pending 510(k) clearance by the United States Food and Drug Administration; not yet available for in vitro diagnostic use in the U.S. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. Disclosures Smit: Beckman Coulter: Employment. Seidel:Beckman Coulter: Employment. Rohrbach:Beckman Coulter: Employment. Magari:Beckman Coulter: Employment. Lo:Beckman Coulter: Employment. Martin:Beckman Coulter: Employment. Tejidor:Beckman Coulter: Employment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".