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Record W2975403621 · doi:10.1542/peds.2019-0925

Autism Screening: Where Do We Go From Here?

2019· letter· en· W2975403621 on OpenAlexaffabout
Lonnie Zwaigenbaum, Jonathon L. Maguire

Bibliographic record

VenuePEDIATRICS · 2019
Typeletter
Languageen
FieldNeuroscience
TopicAutism Spectrum Disorder Research
Canadian institutionsUniversity of TorontoSt. Michael's HospitalWomen and Children’s Health Research InstituteUniversity of Alberta
Fundersnot available
KeywordsMedicineAutismPsychiatry

Abstract

fetched live from OpenAlex

* Abbreviations: ASD — : autism spectrum disorder M-CHAT/F — : Modified Checklist for Autism in Toddlers With Follow-up PPV — : positive predictive value The lengthy diagnostic odyssey experienced by families of children with autism spectrum disorder (ASD) remains a major barrier to early access to ASD therapeutic services. Although accelerating this process has been identified as a top priority,1 there is a polarized debate about whether ASD screening can accomplish this. The American Academy of Pediatrics recommends that all children be assessed by using an ASD screening tool at 18 and 24 months old.2 In contrast, the US Preventive Services Task Force concluded that there was “insufficient evidence to recommend screening for ASD in children aged 18 to 30 months for whom no concerns of ASD have been raised.”3 The issue has been debated passionately,4–6 but without resolution, in part because of limited community-level data regarding screening feasibility, accuracy, and outcomes. The current study by Guthrie et al7 contributes important findings that further inform this debate. The authors demonstrated that universal screening was feasible, with >90% of toddlers screened through a large primary care network by integrating the Modified Checklist for Autism in Toddlers (M-CHAT) With Follow-up (M-CHAT/F) into routine primary health care. Physicians were prompted to administer the … Address correspondence to Lonnie Zwaigenbaum, MD, MSc, Autism Research Centre, Glenrose Rehabilitation Hospital, University of Alberta, E209, 10230 111th Ave, Edmonton, AB T5G 0B7, Canada. E-mail: lonniez{at}ualberta.ca

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.014
metaresearch head score (Gemma)0.062
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.986
Threshold uncertainty score0.116

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0140.062
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.002
Science and technology studies0.0030.003
Scholarly communication0.0060.018
Open science0.0030.004
Research integrity0.0090.014
Insufficient payload (model declined to judge)0.0350.012

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.286
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainEvaluation
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations25
Published2019
Admission routes2
Has abstractyes

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Same venuePEDIATRICSSame topicAutism Spectrum Disorder ResearchFrench-language works237,207