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Malignant Melanoma Extracted from the Common Bile Duct

2011· article· en· W2977288013 on OpenAlexaff
Mark Borgaonkar

Bibliographic record

VenueThe American Journal of Gastroenterology · 2011
Typearticle
Languageen
FieldMedicine
TopicCutaneous Melanoma Detection and Management
Canadian institutionsMemorial University of Newfoundland
Fundersnot available
KeywordsMedicineMelanomaCommon bile ductNauseaSurgeryJaundiceVomitingRadiology

Abstract

fetched live from OpenAlex

Purpose: A 54-year old woman presented with a two-day history of nausea, vomiting and abdominal pain. Her past history was significant for melanoma of the right lower limb, first diagnosed in 2006 and treated surgically. There was local recurrence in 2007 treated surgically again. In 2009 she was found to have metastases to her uterus requiring hysterectomy. Later that year, she had right mastectomy and radiation therapy for breast metastases. In 2010 brain metastases were treated with radiation therapy and subsequently surgery. At the same time, pulmonary and cutaneous metastases were noted. On this occasion her AST peaked at 230 IU/L, ALT 336 IU/L and bilirubin 178 μmol/L. CT scan showed a dilated CBD of 1.8 cm and a distal mass. ERCP was performed and a large, oblong, distal filling defect was seen on fluoroscopy (Image 1). Following sphincterotomy, the duct was explored with a balloon catheter. A red, fleshy mass was extracted and subsequently retrieved with a Roth net (Image 2). Histological analysis confirmed this to be melanoma. Her symptoms resolved and bilirubin fell to 39 μmol/L. Unfortunately, she succumbed to her illness 2 weeks later. Melanoma has previously been reported to metastasize to the CBD. This case is unique in that it is the first ever report of intraductal melanoma actually being extracted from the duct during ERCP. It highlights the unusual behavior of this particular cancer.Figure: No Caption available.Figure: No Caption available.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.243
Teacher spread0.223 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2011
Admission routes1
Has abstractyes

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