Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood
Bibliographic record
Abstract
BACKGROUND: Most researchers have accepted that unipotent progenitors are the predominant components in bone marrow for tissue regeneration. However, the unipotent progenitors for blood components are still unclear. We previously found that erythrocytes are derived from a distinct unipotent progenitors, or erythrocyte sacs. METHODS: In the current study, we investigated if the other types of unipotent blood cell progenitors existed, what was their original morphologies, and the mechanism of their generation in mouse blood. RESULTS: spore-like small progenitors. Another structure was bud-like, contained inclusion, enlarged from less than 10 µm to more than 30 µm, and also released many spore-like small progenitors. Each type of these spore-like progenitors was approximately 1 µm in diameter and could continue to transdifferentiate in circulation. CONCLUSIONS: Our data provide evidence that two types of blood cell restricted progenitors are produced from either filamentary structures or bud-like structures. Both filamentary and bud-like structures were originally released from morphologically distinct, or lineage predetermined tube-shaped structures, or specific niches. Thus, distinct lineages of blood unipotent progenitors are newly produced.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".