EFFECT OF A L-ACTOBACILL US ACIDOPHILS AND CASEI-ENRICHED YOGHURT IN THE PRIMARY PREVENTION OF ANTIBIOTIC-ASSOCIATED DIARRHEA (LACTIC TRIAL)
Bibliographic record
Abstract
Purpose: Antibiotic-associated diarrhea (AAD) is an important problem in hospitalized patients. This randomized, double-blind, placebo-controlled trial assesses the efficacy of a lactobacilli-enriched yoghurt in the primary prevention of AAD. Methods: After the initiation of an antibiotic treatment, 89 adult hospitalized patients receiving antibiotics were randomly assigned to receive a lactobacilli-enriched yoghurt (50 × 109Lactobacillus acidophilus and L. casei) or a placebo (lactoserum devoid of any microorganism), daily. Prophylaxis was given as to cover the entire antibiotic treatment. Follow up was planned to end 21 days after the end of the antibiotic course. The primary end point for efficacy was the occurrence of AAD, as documented by at least three liquid stools in a 24-hour time period. The occurrence of Clostridium difficile-associated diarrhea (CDAD), duration of hospitalization and tolerance to the preparation were also evaluated. Clinical data on individual patients and data on stool frequency and consistency were obtained on a regular basis from hospital medical and pharmacy records. For patients discharged from hospital before the end of follow-up, data was gathered using a standardized questionnaire. Results: AAD developed in 17,1% of patients in the lactobacilli group and in 37,2% of patients in the placebo group (P = 0.039). Fewer patients in the lactobacilli group developed a CDAD from that observed in the placebo group (P = 0.028). Median duration of hospitalization was 8 days in the treatment group, compared to 10 days in the placebo group (P = 0.048). Overall, the prophylaxis was well tolerated, proportion of patients presenting side-effects (for the most part gastrointestinal) being similar between groups (P >0,99). Conclusions: A prophylaxis consisting in the daily administration of a yoghurt containing 50 × 109 lactobacilli (Lactobacillus acidophilus and L. casei) was effective in reducing the occurrence of AAD and CDAD in this sample of 89 adult patients taking antibiotics initially administered in the hospital setting.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".