Vitamin D dose response study in Canadian infants: 25‐hydroxy‐vitamin D status during a 20 week intervention
Bibliographic record
Abstract
The Canadian Paediatric Society (CPS) recommends breastfed infants receive vitamin D supplementation (400 to 800 IU/d) in support of optimal plasma 25‐hydroxy vitamin D (25(OH)D), defined as 75 nM. The objective of this study was to establish a dosage of vitamin D that would support optimal status in 97% of young infants. Healthy term born infants from Montreal (32 girls, 46 boys) were randomized to 400, 800 or 1200 IU vitamin D 3 daily from age 4 wk and plasma 25(OH)D (RIA, Diasorin Inc.) measured at baseline, 4, 8 and 20 wk ( NCT00381914 ; clinicaltrials.gov). Blinded treatments were re‐coded. Repeated measures ANOVA (by ITT) accounting for within‐subject serial correlations demonstrated season of birth, weight, time, treatment and treatment‐time interaction as significant (p<0.01) predictors of 25(OH)D. shows estimated means by time and treatment. Mean 25(OH)D concentrations were higher over time (p<0.01) in dose regimen A vs. other treatments. Using 25(OH)D categories, overall 32% were above 75 nM after the 20 wk intervention. These results suggest that daily dosages of vitamin D from 400 to 1200 IU support a mean 25(OH)D concentration above that associated with deficiency, but the majority do not reach optimal status by 20 wk of supplementation. Estimated mean 25(OH)D ± SE (nM) [% reaching 75 nM]. Time points Treatments A (n=25) B (n=25) C (n=28) Baseline 47.8 ± 3.7 [0.0] 42.8 ± 3.7 [0.0] 41.7 ± 3.8 [4.0] 4 wk 63.4 ± 2.8 [28.6] 44.3 ± 2.8 [0.0] 40.8 ± 2.8 [0.0] 8 wk 57.6 ± 2.4 [5.3] 47.1 ± 2.3 [0.0] 51.7 ± 2.2 [8.7] 20 wk 84.0 ± 5.3 [38.9] 76.7 ± 5.3 [23.5] 77.0 ± 4.6 [33.3] p<0.05 vs treatment‐specific baseline, p<0.05 vs treatment A at same time. Grant Funding Source : Canadian Institutes of Health Research
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".