Outcomes of Newborn Infants With Pulmonary Hypertension Treated With Oral Sildenafil
Bibliographic record
Abstract
Background: Persistent pulmonary hypertension of the newborn (PPHN) is a disease with a high mortality rate. The incidence of PPHN is approximately 0.8 per 1,000 live births. Inhaled nitric oxide remains the treatment of choice, but in areas where inhaled nitric oxide is not available, sildenafil citrate is considered the best alternative vasodilator. We conducted this study to investigate the efficacy of oral sildenafil in treating neonatal pulmonary hypertension. Methods: This is a retrospective study of all newborns diagnosed with PPHN who received oral sildenafil over an 8-year period. Results: A total of 27 newborns were included in the study. The most common primary disease was respiratory distress syndrome. The mortality rate was 44.4%; all newborns with cardiovascular shock at presentation died. Conclusions: Oral sildenafil is a promising medication that can help neonates with mild to moderate PPHN in hospital units where inhaled nitric oxide is not available. Development of a treatment protocol to standardize the care of such infants will positively impact outcomes. Int J Clin Pediatr. 2019;8(2):27-31 doi: https://doi.org/10.14740/ijcp349
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".