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Record W2979900618

Does chondroitin sulphate act as an ‘alarm cue’ in zebrafish?

2019· article· en· W2979900618 on OpenAlexaff
Jasmin Bajwa

Bibliographic record

VenueStudent Research Proceedings · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicZebrafish Biomedical Research Applications
Canadian institutionsMacEwan University
Fundersnot available
KeywordsThigmotaxisZebrafishFish <Actinopterygii>ALARMChondroitinChemistryBiologyFisheryBiochemistryOpen fieldEndocrinologyGlycosaminoglycanEngineering
DOInot available

Abstract

fetched live from OpenAlex

Zebrafish are aquatic organisms that are capable of detecting the injury of others in their species via an olfactory ‘alarm cue’ that is released by injured fish. Chondroitin sulphate, a chemical compound extracted from shark cartilage, has recently been identified as a possible ‘alarm cue’. The aim of this study was to determine whether, and at which concentration, chondroitin sulphate could induce a behavioural response. This was assessed via a dose-response curve in which fish were dosed with varying concentrations of chondroitin sulphate (1, 10, and 100 mg/L), and tested in an open field test followed by a novel object approach test. We assessed the time fish spent in certain zones within the testing arena, the distance each fish moved, and the amount of time fish was immobile. There was a significant increase in the time fish in the 1 mg/L and 100 mg/L groups spent in the thigmotaxis zone during the novel object approach test in comparison to the control condition. This suggests an increase in anxiety-like behaviour with certain doses of chondroitin sulphate. Faculty Mentors: Trevor Hamilton and Michele Moscicki Department: Psychology

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.433
Threshold uncertainty score0.789

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.412
Teacher spread0.383 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

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