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Record W2980305786 · doi:10.1002/em.22339

Application of the adverse outcome pathway framework to genotoxic modes of action

2019· article· en· W2980305786 on OpenAlexaff
Jennifer C. Sasaki, Ashley Allemang, Steven M. Bryce, Laura Custer, Kerry L. Dearfield, Yasmin Dietz, Azeddine Elhajouji, Patricia A. Escobar, Albert J. Fornace, Roland Froetschl, Sheila M. Galloway, Ulrike Hemmann, Giel Hendriks, Heng‐Hong Li, Mirjam Luijten, Gladys Ouédraogo, Lauren Peel, Stefan Pfuhler, Daniel J. Roberts, Véronique Thybaud, Jan van Benthem, Carole L. Yauk, Maik Schuler

Bibliographic record

VenueEnvironmental and Molecular Mutagenesis · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDNA Repair Mechanisms
Canadian institutionsHealth Canada
Fundersnot available
KeywordsAdverse Outcome PathwayGenotoxicityBiologyPopulationComputational biologyToxicologyMode of actionGeneticsToxicityChemistryMedicine

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.028
metaresearch head score (Gemma)0.016
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.028
Threshold uncertainty score0.148

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0280.016
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.003
Bibliometrics0.0050.002
Science and technology studies0.0020.009
Scholarly communication0.0060.005
Open science0.0030.007
Research integrity0.0040.006
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.215
Teacher spread0.210 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations56
Published2019
Admission routes1
Has abstractyes

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