P2‐163: CHARACTERIZING TAUOPATHY RELATED NEUROPATHOLOGICAL AND CHOLINERGIC DYSFUNCTION IN THE ROSTRAL PREFRONTAL CORTEX
Bibliographic record
Abstract
Deficits in working memory and attention are shared clinical features the group of neurodegenerative disorders called tauopathies including Alzheimer's disease (AD), corticobasal degeneration (CBD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). The rostral prefrontal cortex (rPFC) has been implicated as an area vital to working memory and attention, likely due to its connection to regions such as the basal forebrain via cholinergic neurons. In AD, one known aspect of cholinergic dysfunction is differential expression of the acetylcholine degrading enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in the cortex. Despite being involved in working memory and attention, neuropathological and cholinergic changes in the rPFC have not been characterized in AD, CBD, FTD or PSP. The purpose of this study is to identify neuropathological, and cholinergic changes in the rPFC that occur in AD, CBD, FTD and PSP, as compared to cognitively normal controls. The rPFC of sex- and age-matched control, AD, FTD, PSP, and CBD brains were compared. Immunohistochemical techniques were used to examine the distributions of β-amyloid, tau and choline acetyltransferase. Histochemical techniques were used to examine AChE and BChE activity. Preliminary results indicate BChE does not associate with amyloid plaques or tau tangles in PSP in addition to FTD and CBD, as previously described. The results of this study will further our understanding of differential rPFC pathology in neurodegenerative disorders including identifying the role of BChE in cholinergic dysfunction. Examination of the rPFC will facilitate understanding the mechanistic underpinnings of deficits in working memory and executive function in tauopathies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".