P1‐605: THE EFFECTS OF PHYSICAL EXERCISE ON COGNITIVE FUNCTION AMONG OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: THE MEDITATING ROLE OF DEPRESSIVE SYMPTOMS AND SLEEP QUALITY
Bibliographic record
Abstract
Despite current research evidence supporting the cognitive-enhancing effects associated with physical exercise, there is a dearth of study to examine the mediating mechanisms underlying the exercise-cognition relationship. Addressing this research gap is important to further the theoretical understanding of the cognitive benefit of physical exercise, and thereby providing insights on developing exercise interventions which are more effective to optimize the changes on the mediators. With the substantial evidence to suggest the benefits of physical exercise on depressive mood and sleep quality, there is a possibility that the exercise-cognition relationship is mediated by the improvement in these risk factors for cognitive decline. A total of 120 eligible participants were randomly assigned to receive either the group-based moderate-intensity aerobic exercise programme or the health education programme (as attention-placebo control). The Montreal Cognitive Assessment, Geriatric Depression Scale and Pittsburgh Sleep Quality Index were administered at baseline before randomization and right after the completion of the interventions. Generalize Estimating Equation was used to compare the changes in the cognitive function over the pre-test and post-test period between groups. The mediating roles of depressive mood and sleep quality in the exercise-cognition relationship were examined with the PROCESS macro. Participants in the intervention group had a significantly greater improvement than the control group in cognitive function (β= 1.895; 95% Confidential Interval (CI)= 1.421, 2.368; p < 0.001)) over the pre-test and post-test period. The exercise-cognition relationship was significantly mediated by a reduction in depressive symptoms (indirect effect: β= −0.705; 95% CI: −1.028, −0.382) and improved sleep quality (indirect effect: β=−0.205; 95% CI: −0.122, 0.831). Decreasing depressive symptoms and improving sleep quality were firstly identified as part of the possible mechanisms underlying the exercise–cognition relationship. As such, future studies should investigate whether combining exercise interventions with psychological element and sleep hygiene education have considerable benefits on brain health.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.015 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".